Significance of Correction of Metabolic Acidosis on the Cardiovascular DynamicsExperimental Study and Clinical Observation Following Cardiopulmonary Bypass

摘要

The importance of correction of acid-base derangement for the care of surgical patient has been stressed recently. Despite of intensive study of the hemodynamic aspects of its derangement, these results were not entirely consistent. Accordingly, evaluations were made concerning the influence of metabolic acidosis and its correction on myocardial performance and vascular resistance in dogs and clinically the effectiveness of correction of metabolic acidosis on myocardial contractility after an openheart surgery. The result indicated that metabolic acidosis had a considerably adverse effect on the myocardium and the peripheral circulation, and that correction of metabolic acidosis was quite beneficial to restore cardiovascular dynamics.