首页> 外文期刊>Japanese heart journal >Effect of Trichlormethiazide and Captopril on Nitric Oxide Synthase Activity in the Kidney of Deoxycorticosterone Acetate-salt Hypertensive Rats
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Effect of Trichlormethiazide and Captopril on Nitric Oxide Synthase Activity in the Kidney of Deoxycorticosterone Acetate-salt Hypertensive Rats

机译:三氯噻嗪和卡托普利对醋酸脱氧皮质酮盐酸盐高血压大鼠肾脏一氧化氮合酶活性的影响

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Nitric oxide (NO) production is reduced in patients with essential hypertension and in some experimental models. We have investigated the effect of trichiormethiazide and captopril on NO synthase (NOS) activity and glomerular damage in the kidney of deoxycorticosterone acetate (DOCA)-salt hypertensive rats. DOCA-salt rats were induced with weekly injections of DOCA (30mg/kg body weight (BW)) and 1% saline in drinking water after right nephrectomy. As antihypertensive therapies, CAP (captopril, 40mg/kg BW) and TCM (trichlormethiazide, 10mg/kg BW) were given after induction of DOCA-salt hypertension. The increased blood pressure was significantly lowered by TCM, but not by CAP after 5 weeks. Nitrite production in kidney slices was suppressed in DOCA-salt rats, and immunoreactivity for both braintype NOS (B-NOS) in macula densa and endothelial-type NOS (EC-NOS) in renal vessels was decreased. TCM significantly increased the nitrite production in the kidney slices and B-NOS immunoreactivity, whereas these changes were less in CAP. Glomerulosclerosis score was significantly higher in DOCA-salt rats, and TCM ameliorated renal damage more effectively than CAP. These results indicate that the reduced nitrite production in the kidney of DOCA-salt hypertensive rats was increased more effectively by trichlormethiazide than by captopril, via increased immunoreactivity for B-NOS in the macula densa, and prevented renal damage.
机译:在原发性高血压患者和某些实验模型中,一氧化氮(NO)的产生减少。我们已经研究了三甲氰胺和卡托普利对醋酸脱氧皮质酮(盐)高血压大鼠肾脏中NO合酶(NOS)活性和肾小球损害的影响。右肾切除术后,每周注射DOCA(30mg / kg体重(BW))和1%的生理盐水,诱导DOCA-盐大鼠。作为降压疗法,在诱导DOCA-盐高血压后,给予CAP(卡托普利,40mg / kg体重)和中医(三氯甲嗪,10mg / kg体重)。 5周后,中医可显着降低血压升高,但CAP则不会。在DOCA-盐大鼠中,肾脏切片中亚硝酸盐的产生受到抑制,黄斑部脑内脑型NOS(B-NOS)和肾血管内内皮型NOS(EC-NOS)的免疫反应性均降低。中药显着增加了肾脏切片中亚硝酸盐的产生和B-NOS免疫反应性,而CAP中的这些变化较小。在DOCA-盐大鼠中,肾小球硬化评分明显更高,中药比CAP更有效地改善了肾脏损害。这些结果表明,通过增加对黄斑牙本质中B-NOS的免疫反应性,三氯噻嗪比卡托普利更有效地增加了DOCA-盐高血压大鼠肾脏中亚硝酸盐的产生,并防止了肾脏损害。

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