Neuropathological Alterations following Carotid Artery Ligation in Spontaneously Hypertensive and Normotensive Rats

摘要

Neuropathological study with light and electron microscopy was performed in SHR and NR following BCAL. SHR showed early death due to cerebral infarction, while NR with BCAL did not show cerebral death. The posterior communicating arteries connecting the carotid and basilar systems were well developed in SHR as well as NR. Because of paucity of vascular changes in the experimental animals, the cerebral lesions in SHR were attributed to the hemodynamic difference in the both groups.