Clinical, Pathological and Immunohistochemical Findings in Diarrheic Dogs and Evaluation of Canine Parvoviral and Coronaviral Enteritis

摘要

The aim of this study is to examine, clinicopathological findings of naturally occurring diarrhea in dogs and correlate clinical sings with pathological findings of canine parvovirus and coronavirus infection. Hematology, biochemistry, pathology and immunohistochemistry were applied. Vomiting and diarrhea were prominent findings in all affected dogs. The critical values for good prognosis in diarrheic dogs were >2x103 mm-3 total leukocyte count, below 25 mmol L-1 anion gap and >7.36 blood pH at the admission. Diagnosis was made by immunohistochemical examination in died doga??s guts tissue sections. Strong immunopositive reaction were seen in enterocytes, lymphocytes and macrophages in Payera??s patches in both parvovirus and coronavirus cases. Lesions were more severe in dual infection cases. The most important point of the supportive treatment was fluid and electrolyte therapy against to dehydration in all cases and strong relationship was observed in treatment starting time to recovering dehydration and mortality rate.