Metathesis in Natural Product Synthesis

摘要

“Metathesis in Natural Product Synthesis” subtitled ‘Strategies, Substrates and Catalysts’ benefits from a foreword by Robert H. Grubbs, joint recipient of the 2005 Nobel Prize in Chemistry for his work on the development of the metathesis method in organic synthesis. This timely publication focuses on developments in the synthesis of natural products which use as a key step the versatile metathesis reaction catalysed by transition metal complexes, especially ruthenium. While reference to metathetic pathways in obtaining natural products or their mimics is encountered sporadically in many books and articles which primarily deal with metathesis as a catalytic process, to the best of our knowledge this is the first monograph devoted entirely to a systematic treatment of metathesis applications in natural product synthesis. The field has direct relevance for the drug industry, and currently receives a great deal of attention due to the pharmacological activity found in many natural compounds. Therefore, this volume promises to be a very helpful resource.