Total synthesis of prostaglandin J natural products by stereopreservation metathesis

摘要

The present invention generally uses a sterically retained ruthenium olefin metathesis catalyst supported by a dithiolate ligand Δ 12 - relates to the synthesis of prostaglandin J products. Δ The 12 prostaglandin J product was produced with excellent selectivity (> 99% z) and medium to high / good yield (47% to 80% yield, 58% to 80% yield).