Oxidative, inflammatory and cardiometabolic biomarkers of clinical relevance in patients with metabolic syndrome

摘要

Introduction: Obesity is characterized by excessive deposition of fat in adipose tissue and is associated with the development of pathological damage in several metabolic processes that are associated with oxidative stress and inflammation. Objective: To evaluate the levels of adiponectin, inflammatory markers and oxidative markers, with the objective of determining a biomarkers profile in adults that influences the metabolic risk of developing the metabolic syndrome (MetS). Methods: The groups studied included 84 adults (48 Without MetS and 36 With MetS). General and biochemical parameters were determined. Adiponectin levels, inflammatory markers [C-reactive protein (CRP)], interleukin 6 (IL-6), adenosine deaminase (ADA), dipeptidyl peptidase-IV (DPP-IV) and oxidative markers [thiobarbituric acid reactive substances (TBARS), sulfhydryl groups (SH), total ferric antioxidant power (FRAP) and vitamin C] were also measured. Results: The MetS group presented a significant increase in insulin, triglycerides, cholesterol, low-density lipoprotein cholesterol (LDL-C), glutamic-pyruvic transaminase (GPT) and uric acid, as well as gamma-glutamyl transferase (GGT), glutamic-oxaloacetic transaminase (GOT), and vitamin C. Conclusion: The combination of IL-6, ultra-sensitive C-reactive protein (us-CRP), ADA, DPP-IV and the increase of TBARS, with the reduction of vitamin C, SH groups and adiponectin, promote inflammation and compromise insulin sensitivity, thus presenting an active role in the pathogenesis of MetS. These findings are significant because they may assist in monitoring clinical changes, in the prevention of future cardiometabolic events in individuals with MetS, and in the identification of inflammatory and oxidative markers that assist in the monitoring and prevention of MetS.