A Comparative Study of Dexmedetomidine Versus Esmolol for Attenuation of Cardiovascular Response to Laryngoscopy and Endotracheal intubation.

摘要

The present study compares the effects of dexmedetomidine and esmolol on cardiovascular response occurring due to laryngoscopy and endotracheal intubation. A randomised controlled study was carried out on 90 healthy adult patients (ASA I and ASA II) under general anaesthesia. Patients were ran- domly allocated into two groups i.e group E and group D. Group D received dexmedetomidine 0.6μg/kg and group E received esmolol 1mg/kg. Heart rate, systolic blood pressure and diastolic blood pressure were recorded at baseline, at induction and at 1,3,5 and 10minutes after intubation. This study showed that dexmedetomidine (0.6μg/kg) was more effective than esmolol (1mg/kg) for attenuating the car- diovascular response to laryngoscopy and intubation.