A Comparative Study of Dexmedetomidine Versus Esmolol for Attenuation of Cardiovascular Response to Laryngoscopy and Endotracheal Intubation

摘要

The present study compares the effects of dexmedetomidine and esmolol on cardiovascular responseoccurring due to laryngoscopy and endotracheal intubation. A randomised controlled study was carried outon 90 healthy adult patients (ASA I and ASA II) under general anaesthesia. Patients were randomlyallocated into two groups i.e group E and group D. Group D received dexmedetomidine 0.6 μg/kg andgroup E received esmolol 1 mg/kg. Heart rate, systolic blood pressure and diastolic blood pressure wererecorded at baseline, at induction and at 1, 3, 5 and 10 minutes after intubation. This study showed thatdexmedetomidine (0.6 μg/kg) was more effective than esmolol (1mg/kg) for attenuating the cardiovascularresponse to laryngoscopy and intubation.