TRIMETHADIONE AS A MODEL DRUG FOR THE EVALUATION OF HEPATIC DRUG-METABOLIZING CAPACITY IN NORMAL AND D-GALACTOSAMINE INTOXICATED RATS

Einosuke TANAKA; Haruki KINOSHITA; Takemi YOSHIDA; Yukio KUROIWA

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TRIMETHADIONE AS A MODEL DRUG FOR THE EVALUATION OF HEPATIC DRUG-METABOLIZING CAPACITY IN NORMAL AND D-GALACTOSAMINE INTOXICATED RATS

机译：三甲基二酮作为模型药评估正常和D-半乳糖胺氧化的大鼠的肝药物代谢能力

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来源
《Japanese Journal of Pharmacology 》 |1982年第6期| 共页
作者
Einosuke TANAKA; Haruki KINOSHITA; Takemi YOSHIDA; Yukio KUROIWA;
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中图分类药理学 ;
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1. TRIMETHADIONE AS A MODEL DRUG FOR THE EVALUATION OF HEPATIC DRUG-METABOLIZING CAPACITY IN NORMAL AND D-GALACTOSAMINE INTOXICATED RATS [J] . Einosuke TANAKA, Haruki KINOSHITA, Takemi YOSHIDA, Japanese Journal of Pharmacology . 1982 ,第6期

机译：三甲基二酮作为模型药评估正常和D-半乳糖胺氧化的大鼠的肝药物代谢能力
2. In vitro characterization of sarizotan metabolism: hepatic clearance, identification and characterization of metabolites, drug-metabolizing enzyme identification, and evaluation of cytochrome p450 inhibition. [J] . Gallemann D, Wimmer E, Hofer CC, Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2010 ,第6期

机译：sarizotan代谢的体外表征：肝清除率，代谢产物的鉴定和表征，药物代谢酶的鉴定以及细胞色素p450抑制的评估。
3. Pharmacokinetics of NS-49, a phenethylamine class alpha 1A-adrenoceptor agonist. 3rd communication: metabolism in rats, rabbits, dogs and monkeys, and effects on hepatic drug-metabolizing enzyme activities in rats after repeated administration. [J] . Mukai H, Watanabe S, Morino A Arzneimittel-Forschung: =Drug Research . 1999 ,第7期

机译：NS-49（一种苯乙胺类α1A-肾上腺素受体激动剂）的药代动力学。第三次交流：反复给药后，大鼠，兔子，狗和猴子的代谢以及对大鼠肝药物代谢酶活性的影响。
4. Structure-Activity Relationship and Substrate-Dependent Phenomena in Effects of Ginsenosides on Activities of Drug-Metabolizing P450 Enzymes [C] . Miao Hao, Yuqing Zhao, Peizhan Chen, 第四届国际分子模拟与信息技术应用学术会议（The 4th International Conference of Molecular Simulations and Applied Informatics Technologies）论文集 . 2008

机译：人参皂甙对药物代谢性P450酶活性的影响与结构活性关系和底物依赖现象
5. Knowledge discovery and prediction modeling of protein-drug binding kinetics by integrating machine learning, normal mode analysis and molecular dynamics simulation. [D] . Chiu, See Hong. 2015

机译：通过集成机器学习，正常模式分析和分子动力学模拟，对蛋白质-药物结合动力学进行知识发现和预测建模。
6. The effects of diltiazem on hepatic drug metabolizing enzymes in man using antipyrine trimethadione and debrisoquine as model substrates. [O] . H Sakai, S Kobayashi, K Hamada, 1991

机译：以安替比林丁苯二酮和地布异喹为模型底物地尔硫卓对人体肝药物代谢酶的影响。
7. Evaluation of the induction of hepatic drug-metabolizing enzymes in the rat and mouse treated with temazepam using trimethadione as the indicator. [O] . Yukio F. KITAGAWA, Masaaki KATAHIRA, Katsuichi MATSUDA, 1985

机译：用Trimethadione作为指示剂对大鼠肝药物代谢酶诱导肝药物代谢酶的评价。

TRIMETHADIONE AS A MODEL DRUG FOR THE EVALUATION OF HEPATIC DRUG-METABOLIZING CAPACITY IN NORMAL AND D-GALACTOSAMINE INTOXICATED RATS

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