Pulmonary function in patients with ulcerative colitis and its relationship with disease severity

摘要

Background and Aim Ulcerative colitis (UC) patients have several extraintestinal and systemic manifestations. As studies on the frequency and predictors of pulmonary involvement in patients with UC are inconsistent, we undertook this prospective study. Methods Eighty‐seven patients with UC (in remission 49, 56.3%, active disease 38, 43.6%, median age: 40 years, range: 16–66, 55, 62.2% males) and 50 healthy controls (median age: 38 years, range: 14–69, 34, 68% males) underwent pulmonary function tests (PFTs) including forced expiratory volume in 1 s (FEV₁), forced vital capacity (FVC), Tiffeneau value (FEV₁/FVC), mid‐expiratory flow rate, and diffusion lung capacity for carbon monoxide with spirometer. Results Subjects with UC and control were comparable in age and gender. PFT was abnormal in 24 (27.5%) patients (active disease 15/38, 39.4%, remission 9/49, 18.4%) and 1 (2%) control ( P Conclusion UC patients with active disease have abnormal pulmonary functions with predominant involvement of small airways. Active UC was more often associated with abnormal PFT than the disease in remission.