Lipid-Based System Introduces a Novel Approach for an HIV Vaccination

摘要

HIV is one of the deadliest pandemics of modern times, having caused 35 million deaths around the world. While researchers and clinical workers have identified antigens and antibodies necessary to validate diagnosis and have developed antiviral drugs to suppress HIV replication, we still do not have an effective means to prevent and fight the infection. Immunological obstacles are a significant barrier to designing an efficient HIV vaccine. In addition, clinical trial failures have demonstrated the need for novel approaches to identify relevant antigens and adjuvants, as well as for better delivery systems. Innovation based on engineered nanoparticles (NPs) can help overcome these obstacles. A team from CEA-Leti recently demonstrated a concept of an HIV vaccine that enhances an adjuvant’s effect, delivered with pinpoint accuracy in the body. This nanoparticulate system is made of bio-assimilable lipids, called LipidotsTM. The following will summarize the immunological obstacles, as well as previous trial failures and explain how the Lipidot technology points the way toward an effective new HIV vaccine.