Biological Evaluation of Newly Synthesized Isoxazole Derivatives

摘要

A new bis-isoxazole derivative were synthesized and characterized by the spectral and analytical techniques. The compounds were prepared by the cyclo-addition reaction and comparatively studied by antimicrobial screening with different strains of gram positive and gram negative bacteria showed considerable against bacterial growth. The plasmid DNA interaction with compounds revealed the complete cleavage in 1c and 1d compounds, whereas in other compounds cleaved partially from supercoiled in to linear stranded DNA under UV-visible spectroscopic window. The differential DNA damage beside with H2O2 and light, compound exhibited cleavage in light.