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Near-Infrared Fluorescence Optical Imaging and Tomography

机译:近红外荧光光学成像和层析成像

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The advent of recent advances in near-infrared laser diodes and fast electro-optic detection has spawned a new research field of diagnostic spectroscopy and imaging based on targeting and reporting exogenous fluorescent agents. This review seeks to concisely address the physics, instrumentation, advancements in tomography, and near-infrared fluorescent contrast agent development that promises selective and specific molecular targeting of diseased tissues. As an example of one area of the field, recent work focusing on pharmacokinetic analysis of fluorophores targeting the epidermal growth factor receptor (EGFR) is presented in a human breast cancer xenograft mouse model to demonstrate specificity of molecularly targeted contrast agents. Finally, a critical evaluation of the limitations and the opportunities for future translation of fluorescence-enhanced optical imaging of deep tissues is presented.
机译:近红外激光二极管和快速电光检测的最新进展的出现催生了基于靶向和报告外源荧光剂的诊断光谱学和成像技术的新研究领域。这篇综述旨在简明地论述物理,仪器,层析成像技术的进步以及近红外荧光造影剂的发展,这些疾病有望对病变组织进行选择性和特异性的分子靶向。作为该领域的一个实例,在人类乳腺癌异种移植小鼠模型中提出了针对靶向表皮生长因子受体(EGFR)的荧光团的药代动力学分析的最新工作,以证明分子靶向造影剂的特异性。最后,提出了对局限性和未来翻译的深入组织荧光增强光学成像的机会进行严格评估。

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