Serotonin Gene (5-HT) Polymorphisms and Psychiatric Comorbidities in Egyptian Patients with Temporal Lobe Epilepsy

摘要

Background: The relatively high prevalence of neuropsychiatric comorbidities in TLE patients suggests shared mechanisms and/or substrates between these two conditions. there are many evidences to support the hypothesis of an involvement of serotonin in the neurobiology of TLE, and so alterations in serotonin-related genes may be involved in higher susceptibility to psychiatric disease in these individuals Objective: To investigate the effect of 5-HTTLPR and 5-HTTVNTR polymorphisms in the 5-HTT gene and the C-1019G polymorphism in the 5-HT1A gene in psychiatric comorbidities in Egyptian patients with temporal lobe epilepsy. Methods: 50 patients with temporal lobe epilepsy were submitted to the Arabic version of the PSE-10 of the Schedules of Clinical Assessment in Neuropsychiatry (SCAN) and other detailed neuropsychiatric scales and then the influence of 5-HTTLPR and 5-HTTVNTR polymorphisms in the 5-HTT gene and the C-1019G polymorphism in the 5-HT1A gene in psychiatric comorbidities of TLE was evaluated. Results: Psychiatric comorbidities were present in 70% of our patients. The most frequent psychiatric comorbidities were mood disorders (56%). Most of our patients with psychiatric disorders were women (65.7%). There was a higher significant frequency of CC homozygous repeat in C-1019G polymorphism in temporal lobe patients with neuropsychiatric comorbidities (p0.05). There was significant higher score of HAM-A in SS genotype for 5-HTTLPR than SL and LL genotypes (p0.05). Patients with 12/12 genotype had a significant higher score of HAM-D than other genotypes for 5-HTTVNTR polymorphism (p0.05). Conclusion: There is a possible role for 5-HT gene polymorphisms in molecular mechanisms involved in psychiatric comorbidities in TLE. [Egypt J Neurol Psychiat Neurosurg.  2014; 51(3): 351-359] Key words: Temporal lobe Epilepsy; Serotoninergic system; 5-HTT; 5-HT1A; Psychiatric co morbidities.