The antioxidant effect of ?2-cyclodextrin nano-sized inclusion compound (clathrate) with benzoic acid in vitro

摘要

This study provides the information on the synthesis of a novel inclusion complex (clathrate) of β-cyclodextrin with pentaerythritoltetrabenzoate and its antioxidant activity in vitro. On the models of ascorbate-dependent and NADPH lipid peroxidation in rat liver microsomes substrate the antioxidant and antiradical activities of this clathrate were shown. Considering both the obtained data and the structural specificity of the clathrate, it prognostically appears the argument for the application of this complex compound in vivo with minimizing potential side effects, particularly in view of kidney apparatus.