Evaluation of Immunomodulatory activity of Solanum xanthocarpum fruits aqueous extract

摘要

Solanum xanthocarpum is widely recognized in Ayurvedic system of Indian medicine for tratment of respiratory problems. This plant is also known to be important rejuvenators and is useful in several chronic ailments. The present study was undertaken to explore the immunomodulatory activity of the aqueous extracts of Solanum xanthocarpum (family:Solanaceae) fruits on haematological parameter and neutrophil adhesion test using cyclophosphamide induced immunosuppression model. The extent of protection against immunosuppression was evaluated after 14 days of respective drug administration. The aqueous extract of fruits of Solanum xanthocarpum showed pronounced immunoprotective activity by increasing the %Hb, RBC, total WBC count and % neutophils at a dose of 100mg/kg body weight. Phytochemical screening of aqueous extracts of the plant showed presence of carbohydrates, glycosides, saponin, flavonoids, steroids, phenols, triterpenoids and diterpenes.