Acrokeratoelastoidosis is a rare palmoplantar keratoderma. We report the case of a 32-year old man with multiple keratotic papules and plaques on the peripheral margins of his hands and feet. Histopathologic evaluation showed compact orthokeratosis; Verhoeff van Gieson stain showed thin and fragmented elastic fibers. The differential diagnosis includes focal acral hyperkeratosis, which has a similar presentation but with normal elastic fibers. Treatment of acrokeratoelastoidosis is often disappointing, with minimal response to topical glucocorticoids, keratolytics, retinoids, cryotherapy, and lasers.
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机译:角化皮角化病是一种罕见的掌plant角化病。我们报告了一个32岁的男人的情况,他的手和脚的外围边缘有多个角化丘疹和斑块。组织病理学评价显示为紧凑型角膜塑形; Verhoeff van Gieson染色显示弹性纤维细且破碎。鉴别诊断包括局灶性髋关节角化过度,表现相似,但弹性纤维正常。上肢角化异常的治疗通常令人失望,对局部糖皮质激素,角质层分离药,类维生素A,冷冻疗法和激光的反应最小。
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