A Highly Efficient Method for Synthesis of Novel 6,6'-(1,4-Phenylene)bis(4-phenylpyrimidin-2-OL/-2-amine/2-thiol and Evaluation of their Biological Activities

摘要

Three novel bis-heterocycles namely 6,6'-(1,4-phenylene)bis(4-phenylpyrimidin-2-ol), 6,6'-(1,4-phenylene)bis(4-phenylpyrimidin-2-amine) and (6,6'-(1,4-phenylene)bis(4-phenylpyrimidin-2-thiol) have been synthesized by treating chalcone and bisnucleophiles over MgFe2O4 magnetic nanoparticle to yield the bis-pyrimidine analogues in good yields in very short reaction time. The newly synthesized compounds were exhibited a good range of antimicrobial activities.