Design and synthesis of some novel imidazole derivatives as potentantimicrobial and antimalarial agents

摘要

Some new 2-substituted aryl-4-fluoro phenyl-5-(2-Chloropyridinyl)-1H-imidazole derivatives have been synthesized by the reaction of 2-(2-chloropyridin-4-yl)-1-(4-fluorophenyl) ethanone [obtained by the reaction of ethyl -4- fluoro benzoate with 2-chloro-4-methylpyridine] with selenium dioxide in dioxane followed by cyclisation with substituted aryl(or hetero aryl)aldehyde in presence of acetic acid and ammonium acetate. All the synthesized compound were characterized by elemental analysis, 1H NMR and LCMS and also screened for their in- vitro antimicrobial activity against two gram positive (Streptococcus pyogenes and Staphylococcus aureus) and two gram negative bacteria (Pseudomonas aeruginosa and Escherichia coli) along with antifungal and antimalarial activity