Protective effect of leaf extracts of Ximenia Americana Linn. on Acetaminophen induced hepatotoxicity in rats

摘要

The extracts of Ximenia americana Linn.were studied to evaluate the Hepatoprotective activity in acetaminophen induced hepatotoxicity in rats. The plant extracts (200 and 400 mg/kg, p.o) showed a remarkable Hepatoprotective activity against acetaminophen induced hepatotoxicity as judged from the serum marker enzymes and Liver tissues. Acetaminophen induced significant rise in Aspartate amino transferase (AST), Alanine amino transferase (ALT), Alkaline phosphatase (ALP), Total Bilirubin, and Gama glutamate transpeptidase(GGTP), with reduction in total protein content. Treatment of rats with different doses of plant extracts (200 and 400 mg/kg, p.o) significantly (P0.05) altered serum marker enzymes levels to normal against acetaminophen treated rats. Histopathological liver samples were compared with standard (Silymarin treated). The results of this study indicates that Ximenia americana Linn. leaves have potent Hepatoprotective action against acetaminophen induced hepatotoxicity in rats.