Evaluation of Araucaria heterophylla Gum as a Binder in Tablet Formulations

摘要

Introduction: The present study was focused on the isolation and purification of natural gum from the bark exudates of Araucaria heterophylla tree. Polysaccharides were isolated by precipitation method and purified. Tablets were formulated by wet granulation technique with various concentrations of the gum using Aceclofenac as a model drug. The formulation blend was subjected to drug excipient compatibility. Three batches of the formulations F1, F2 and F3 were prepared using 5%, 7.5% and 10%, gum concentrations respectively.Materials and methods: Gum was isolated from the bark of Araucaria heterophylla tree and purified. Aceclofenac drug was obtained as a gift sample from Micro labs Pvt Ltd, Hosur. All other chemicals used were obtained from SD fine chemicals Mumbai. 1) Extraction and Purification of the gum 2) Phytochemical and physicochemical investigation of the gum. Results and Discussion: The granules were evaluated for pre-compressional parameters such as bulk density, tapped density, compressibility index, Hauser ratio and angle of repose. The tablets were evaluated for weight variation, hardness, friability, disintegration time and in vitro dissolution studies.Conclusion: As the concentration of the gum increased the disintegration time increased. Also, the dissolution time enhanced as the proportion of the gum was increased indicating the binding efficiency was directly proportional to the concentration of the gum.