OVER-COATED CHEWING GUM FORMULATIONS INCLUDING TABLETED CENTER

摘要

Methods and products for delivering a medicament or agent to an individual areprovided as well as methods for producing the product. The product includes acoating having a medicament or agent. The medicament or agent is presentwithin the coating that surrounds a tableted gum center (the water solubleportion and a water insoluble base portion). By chewing the gum, themedicament or agent is released from the product. Continuing to chew thechewing gum creates a pressure within the buccal cavity forcing the agent ormedicament directly into the systemic system of the individual through theoral mucosa contained in the buccal cavity. This greatly enhances theabsorption of the drug into the systemic system as well as the bioavailabilityof the drug within the system.