Elucidation of In-vitro toxicity screening of carboxylated Multi-WalledCarbon Nanotubes using Red Blood Cells

摘要

Carbon nanotubes (CNTs) possess variable hemolysis activity against Red Blood Cells (RBCs). Hemolysis Activity of CNT varies according to functional group present on CNT surface, concentration of CNT and length of exposure period. There is a need to have more studies reporting hemolysis by carbon nanotubes. This study attempts to provide further incite to understand Hemolysis of RBC by Carbon nanotubes. In this study, we have studied hemolysis activity on RBCs by carboxylated Multi-Walled Carbon Nanotubes (MWCNT-COOH) within 1 hour using an universal method of determining nanoparticle hemolytic properties in vitro. This study provides an useful incite to understand ability of carbon nanotubes to cause hemolysis of RBCs. This study clearly indicating that hemotoxicological profile is a mandatory step toward the development of clinically relevant medications or contrast agents based on carbon nanotubes.