L-Proline catalyzed one pot synthesis of novel 1,4-dihydro pyridine derivatives

摘要

Multi component, one pot synthesis of diethyl/ dimethyl 4-(2-butyl-4-chloro-1H-imdazol-5-yl)-2,6-dimethyl-1,4- dihydro pyridine-3,5-dicarboxylayte derivatives 3(a–f) form the condensation of N-alkyl-2-butyl-4-chloro-1Himidazole- 5-carbaldehydes 1(a–c), methyl/ethyl acetoacetate (2), ammonium carbonate has been described using Lproline as a environmentally benign catalyst. L–proline catalyzed reaction provides a green and inexpensive preparation method for synthesis of above compounds.