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The development of primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoproliferative disorder at the site of a melanoma excision scar

机译:黑色素瘤切除疤痕部位原发性皮肤CD4 +中小型多形性T细胞淋巴增生性疾病的发展

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Primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoproliferative disorder (PCSM-LPD) is a rare and low-grade form of cutaneous T-cell lymphoma (CTCL), representing 2% of all primary cutaneous lymphomas. Because of its rarity, the etiology or exact clinicopathology of PCSM-LPD remains unclear. We present the first case of PCSM-LPD, to our knowledge, arising at a past melanoma excision site. A 72-year-old woman with a past medical history significant for melanoma-in-situ excised 36 years ago presented to our clinic for evaluation of a single, erythematous plaque of the posterior arm within a melanoma excision scar. A biopsy was performed, revealing PCSM-LPD. Reports of the development of other T-cell lymphoproliferative disorders after prior skin trauma such as chemical burns, thermal injury, and mechanical trauma exist in the literature. Physicians should be aware of the possibility of the appearance of T-cell lymphoproliferative disorders at the site of scars or prior trauma with a time lag of months to years.
机译:原发性皮肤CD4 +中小型多形性T细胞淋巴增生性疾病(PCSM-LPD)是一种罕见的低级皮肤T细胞淋巴瘤(CTCL),占所有原发性皮肤淋巴瘤的2%。由于其稀有性,PCSM-LPD的病因或确切的临床病理学仍不清楚。据我们所知,我们介绍了第一例PCSM-LPD,发生在过去的黑色素瘤切除部位。一位36年前切除病史,对黑素瘤就诊有重要意义的72岁妇女被送往我们的诊所,以评估黑素瘤切除疤痕内后臂的单个红斑。进行活检,发现PCSM-LPD。先前的皮肤创伤,例如化学性烧伤,热损伤和机械性创伤后,其他T细胞淋巴组织增生性疾病发展的报道也存在于文献中。医师应意识到在疤痕或先前创伤部位出现T细胞淋巴增生性疾病的可能性,这需要数月至数年的时间。

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