Synthesis, characterization and antibacterial activity of alkyl, benzyl and chloro substituted benzyl derivatives of nitroketene dithioacetals

摘要

Nitromethane (1) upon treatment with Carbon disulfide (2) under ice cold condition in presence of dry methanol / Potassium hydroxide gave dipotassium salt of nitroketene dithioacetal (3). Further treatment of dipotassium salt (3) with alkyl and substituted chloro benzyl bromide furnished bis S,S – alkyl and Substituted chlorobenzyl derivatives (4-10). The structure of the synthesised compounds was characterised using UV, IR, 1H and 13C NMR spectral evidences. The antibacterial activities of products (3-10) were evaluated using Disc-Diffusion method.