In vivo anti-inflammatory and in vitro antioxidant activities of Genista quadriflora Munby extracts

摘要

The present study aims to investigate in vivo anti-inflammatory and in vitro antioxidant activities of Genista quadriflora extracts. The n-butanol extract of this plant was evaluated in Wistar Albinos rats for anti-inflammatory activity using carrageenan-induced hind paw edema model. Antioxidant properties of n-butanol and ethyl acetate extracts were assayed by scavenging abilities on 1, 1-diphenyl-2-picrylhydrazyl (DPPH), lipid peroxidation and total phenolic content (TPC) using spectrophotometric method. Oral treatment with n- butanol extract of Genista quadriflora elicited an inhibitory activity on the development of the paw edema induced by carrageen. This extract showed a significant reduction (p 0.001; p 0.01) in the paw edema volume in a dose-dependent with a maximum that reaches 100 and 200 mg/kg. The n-butanol extract showed anti-inflammatory activity, while all the extracts showed significant antioxidant activity in vitro.