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Genome-wide gene expression dataset used to identify potential therapeutic targets in androgenetic alopecia

机译:全基因组基因表达数据集,用于确定雄激素性脱发的潜在治疗靶标

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The microarray dataset attached to this report is related to the research article with the title: “A genomic approach to susceptibility and pathogenesis leads to identifying potential novel therapeutic targets in androgenetic alopecia” (Dey-Rao and Sinha, 2017) . Male-pattern hair loss that is induced by androgens (testosterone) in genetically predisposed individuals is known as androgenetic alopecia (AGA). The raw dataset is being made publicly available to enable critical and/or extended analyses. Our related research paper utilizes the attached raw dataset, for genome-wide gene-expression associated investigations. Combined with several in silico bioinformatics-based analyses we were able to delineate five strategic molecular elements as potential novel targets towards future AGA-therapy.
机译:该报告所附的微阵列数据集与标题为“易感性和发病机理的基因组方法可确定雄激素性脱发症的潜在新治疗靶标”的研究文章相关(Dey-Rao和Sinha,2017)。在遗传易感人群中,雄激素(睾丸激素)诱发的男性型脱发被称为雄激素性脱发(AGA)。原始数据集可以公开使用,以进行关键和/或扩展分析。我们的相关研究论文利用所附的原始数据集,进行了全基因组基因表达相关的研究。结合基于计算机生物信息学的几种分析,我们能够确定五个战略分子元素,将其作为未来AGA治疗的潜在新靶标。

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