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MIRFILTER: EFFICIENT NOISE REDUCTION METHOD TO IDENTIFY MIRNA AND TARGET GENE NETWORKS FROM GENOME-WIDE EXPRESSION DATA
MIRFILTER: EFFICIENT NOISE REDUCTION METHOD TO IDENTIFY MIRNA AND TARGET GENE NETWORKS FROM GENOME-WIDE EXPRESSION DATA
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机译:过滤器:一种有效的降噪方法,可从全基因组表达数据中鉴定miRNA和目标基因网络
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摘要
A computer implemented method of identifying potential micoRNA targets and biomarkers comprises receiving data identifying a first set of mRNA sequences into computer accessible memory. Each mRNA sequence in the first set has a region that is upstream of a translation start site, a region that is downstream of a translation stop site, and an open reading frame. The method further comprises receiving data identifying a second set of microRNA (miRNA) sequences into the computer accessible memory. Each microRNA sequence has a 5' miRNA section and a 3' miRNA section. Each mRNA sequence is characterized by an expression pattern in the first set as being up-regulated, down-regulated, or uncharged as compared to a control sample and each miRNA sequence in the second set as being up-regulated, down-regulated, or uncharged as compared to the control sample. It is then determined which mRNA sequences from the first set are susceptible to being regulated by microRNA from the second set. A set of consistent relationships is identified between the miRNA and the mRNA determined from the mRNAs that have been characterized.
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