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Ciliated muconodular papillary tumor of the lung: The risk of false-positive diagnosis in frozen section

机译:纤毛黏液性肺乳头状肿瘤:冰冻切片中假阳性诊断的风险

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Ciliated muconodular papillary tumor (CMPT) is newly-defined low-grade malignant tumor, characterized as papillary tumor consisting of ciliated columnar, goblet, and basal cells. We present one case of pulmonary peripheral neoplasm misdiagnosed as mucinous adenocarcinoma. Pathologic findings showed, centrally, cystic papillary growth consisting of ciliated columnar, goblet, and basal cells, and peripherally, some tumor cells spread along the adjacent alveolar walls, in a lepidic fashion, and floating in pool of mucin. Tumor cells had bland nuclei, and no mitotic activity was observed. This had been initially misdiagnosed as mucinous adenocarcinoma in frozen section. We reviewed previous articles as well as permanent and frozen slides. In conclusion, in order to reduce the possibility of false positives, it is important to be aware that CMPT is a rare form of peripheral mucin-producing tumor with characteristic histologic findings.
机译:纤毛状乳头状乳头状肿瘤(CMPT)是新近定义的低度恶性肿瘤,其特征是由纤毛状柱状,杯状和基底细胞组成的乳头状肿瘤。我们提出一例被误诊为粘液性腺癌的肺周围肿瘤。病理结果表明,中央有囊性乳头状生长,由纤毛的柱状,杯状和基底细胞组成,外围有一些肿瘤细胞以鳞状的方式沿相邻的肺泡壁扩散,并漂浮在粘蛋白池中。肿瘤细胞具有平淡的细胞核,未观察到有丝分裂活性。最初在冰冻切片中被误诊为粘液性腺癌。我们回顾了以前的文章以及永久和冻结的幻灯片。总之,为了减少假阳性的可能性,重要的是要意识到CMPT是具有特征性组织学发现的外周粘蛋白生成肿瘤的一种罕见形式。

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