Joint Annual Scientific Meeting 2009

摘要

Background: The objective of this study was to evaluate circulating adipokines concentration in children with and without OSA and to determine the effects of treatment for OSA on their plasma concentration. Methods: Children with habitual snoring and symptoms suggestive of OSA were consecutively recruited. Their parents completed a sleep apnea symptom questionnaire, and the subjects underwent physical examination and an overnight polysomnography (PSG). OSA was diagnosed if obstructive apnea index (OAI) >1. Fasting serum adiponectin, leptin and lipid profile were taken after overnight PSG. The subjects were divided into obese, non-obese, with and without OSA for comparison. Results: 141 children of whom 96 were boys, with a median (IQR) age of 10.8 (8.5-12.8) years were recruited. Forty-three subjects were found to have OSA. Subjects with OSA did not have significant different adiponectin and leptin concentrations than those without OSA for both obese and non-obese groups. Stepwise multiple linear regressions revealed that systolic blood pressure (SBP), age, HDL-C and BMI z-score were independently associated with adiponectin, while diastolic blood pressure (DBP), TG, height and BMI z-score were independently associated with leptin concentration. Sixteen OSA children underwent treatment and there was reduction in their plasma adiponectin concentration after intervention [pre vs. post-adiponectin, 9.40 (7.2) vs. 7.03 (5.6), P=0.046]. Conclusion: Body mass index rather than OSA was the main determinant of adipokines in children