THE IMPACT OF HEPATITIS C VIRUS INFECTION ON KIDNEY TRANSPLANTATION OUTCOMES: A SYSTEMATIC REVIEW OF 18 OBSERVATIONAL STUDIES

摘要

Background: Hepatitis C virus (HCV) infection occurs in 0% to 51% of dialysis patients, and many HCV-positive patients are urged to undergo kidney transplantation. However, the outcome of renal transplantation in HCV-positive recipients is unknown.Objectives: Our review aimed to address the outcomes of renal transplantation recipients (RTRs) following kidney transplantation.Materials and Methods: We selected studies that used the adjusted relative risk (aRR) and 95% CI of all-cause mortality and graft loss in HCV-positive compared with HCV-negative RTRs as study endpoints. Cox proportional hazard analysis was used in all studies to calculate the independent effects of HCV infection on RTR outcomes. Sixteen retrospective cohort studies and 2 clinical trials were selected for our review. Sixteen studies were related to patient survival, and 12 examined graft survival.Results: The combined hazard ratio in HCV-infected recipients was 1.69-fold (1.33-1.97, pConclusions: Although HCV-infected RTRs have worse outcomes than HCV-negative RTRs, kidney transplantation is the preferred treatment for patients with HCV infection and end-stage renal disease.