Dynamic changes in serum chloride concentrations during worsening of heart failure and its recovery following conventional diuretic therapy: A single‐center study

摘要

Background and aims Few data are available regarding the dynamic changes in the serum chloride concentrations in heart failure (HF) pathophysiology. The aim of the present study was to investigate changes in the serum chloride concentration under worsening HF and its recovery following conventional diuretic therapy. Methods Blood test data, including measurements of serum albumin/solutes and b‐type natriuretic peptide, at both worsening and recovery of HF status, were obtained from 47 patients with definite HF. Results Ambulatory patients with HF were enrolled and followed up at the outpatient clinic of Nishida Hospital between June 2003 and March 2009. From clinically stable to worsening HF, the serum sodium concentration increased from (mean?±?SD) 139?±?4.1 to 141?±?5.07?mEq/L ( P Conclusion Under conventional diuretic therapy, greater changes occur in the serum chloride concentration than in the serum sodium concentration under HF state transitions, suggesting that chloride dynamics might contribute more to HF pathophysiology under such therapeutic circumstance.