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Changes in expression of WT1 isoforms during induced differentiation of the NB4 cell line | Haematologica

机译:NB4细胞系诱导分化过程中WT1亚型表达的变化血液学

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The levels of expression of WT1 gene and WT1+17AA isoforms rapidly decreased during the differentiation of NB4 cells induced by all-trans retinoic acid; this decrease was conversely related to the dynamic changes of CD11b positive cells, indicating that the abnormally high expression of WT1 gene and WT1+17AA isoforms was associated with a block of NB4 cell differentiation.
机译:在全反式维甲酸诱导的NB4细胞分化过程中,WT1基因和WT1 + 17AA亚型的表达水平迅速降低。相反,这种减少与CD11b阳性细胞的动态变化有关,表明WT1基因和WT1 + 17AA亚型的异常高表达与NB4细胞的分化有关。

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