Comparison of Apixaban and Low Molecular Weight Heparin in Preventing Deep Venous Thrombosis after Total Knee Arthroplasty in Older Adults

摘要

Purpose To compare the effect of apixaban and low molecular weight heparin (LMWH) in the prevention and treatment of deep venous thrombosis (DVT) after total knee arthroplasty in older adult patients. Materials and Methods A total of 220 patients (average age of 67.8±6.4 years) undergoing total knee arthroplasty were randomly selected as research subjects and were divided into apixaban and LMWH groups (110 in each group). Results The incidence of DVT was lower in the apixaban group than in the LMWH group (5.5% vs. 20.0%, p =0.001). Activated partial thromboplastin times (35.2±3.6 sec vs. 33.7±2.2 sec, p =0.010; 37.8±4.6 sec vs. 34.1±3.2 sec, p Conclusion Apixaban, which elicits fewer adverse reactions and is safer than LMWH, exhibited better effects in the prevention and treatment of DVT after total knee arthroplasty in older adults.