A Novel Association between Lysyl Oxidase Gene Polymorphism and Intracranial Aneurysm in Koreans

摘要

Purpose Lysyl oxidase ( LOX ) controls the cross-linking and maturation of elastin and collagen fibers. In this study, we investigated the association between LOX gene polymorphisms and intracranial aneurysm (IA) formation in a homogeneous Korean population. Materials and Methods This cross-sectional study involved 80 age-sex matched patients with IA and controls. Fisher's exact test was performed to analyze allelic associations between ten single nucleotide polymorphisms (SNPs) and IA, including 41 ruptured and 39 unruptured cases. Haplotype-specific associations were analyzed using the omnibus test estimating asymptotic chi-square statistics. Results Of ten SNPs, three SNPs (rs2303656, rs3900446, and rs763497) were significantly associated with IA ( p ?5]. Meanwhile, the A allele of rs2303656 showed a preventive effect against IA formation ( p =8.2×10?4). Seventeen of 247 haplotype structures showed a suggestive association with IA (asymptotic p ?5). However, there was no association between aneurysm rupture and the LOX gene. Conclusion This preliminary study indicated that LOX gene polymorphisms, such as rs2303656, rs3900446, and rs763497, may play crucial roles in IA formation in the Korean population. Our novel findings need to be validated in a large-scale independent population.