赖氨酰氧化酶基因多态性与宫颈鳞癌易感性

摘要

目的 研究徐州地区汉族人群中,赖氨酰氧化酶基因(LOX)G473A多态性和宫颈鳞癌易感性的相关性.方法 应用PCR和琼脂糖凝胶电泳结合EB显色方法检测479例宫颈鳞癌患者和525例健康对照者LOX G473A多态基因型频率,统计分析其与宫颈鳞癌的关联性.结果 2组临床资料的差异无统计学意义(P>0.05).基因分型结果显示基因型为GA和AA的个体宫颈鳞癌易感性明显增高(P<0.05).结论 LOX G473A多态性与宫颈鳞癌易感性关联,且可能对徐州地区宫颈鳞癌风险预测及发病机制研究具有重要意义.%Objective To investigate the association of lysyl oxidase(LOX)G473A polymorphism and the suscepti-bility to cervical squamous carcinoma(CSC)in the Han ethnic population of Xuzhou.Methods PCR and agarose elec-trophoresis combined with ethidium bromide staining were applied to determine the frequency of genotypes LOX G 473A in 479 CSC patients and 525 healthy subjects,and analyze its relationship between genotyping frequency and CSC suscepti -bility.Results No significant difference was found in any clinicopathological features.CSC Patients with genotypes GA and AA had remarkably increased susceptibility(P<0.05).Conclusions LOX G374A is associated with CSC suscep-tibility,which is vital to predict CSC and illustrate pathogenesis in Xuzhou.