Serum levels of OPG, RANKL and RANKL/OPG ratios in newly-diagnosed patients with multiple myeloma. Clinical correlations | Haematologica

摘要

Serum levels of OPG and RANKL and their clinical correlations were analyzed in 66 newly–diagnosed patients with multiple myeloma (MM). RANKL and RANKL/OPG ratios were significantly increased in advanced clinical stages and high grade myeloma bone disease (MBD), while OPG showed a tendency to decrease. Renal failure modified the expression of OPG. RANKL and RANKL/OPG ratios are informative markers for myeloma tumor burden and MBD.