Comparative Study of the Therapeutic Effects of Two Corpus Luteum Support Regimens on Patients with Frozen Embryo Transfer

摘要

Aim: To investigate the efficacy of two corpus luteum support programs in patients with frozen embryo transfer (FET). Methods: A retrospective analysis of the complete clinical data of 340 patients undergoing in vitro fertilization embryo transfer in the Department of Reproductive Medicine, Jingzhou Central Hospital from September 2016 to July 2018. These patients were divided into group A and B according to the luteal support program. We compared the clinical outcomes of the two corpus luteum preparations by comparing the laboratory parameters of the two groups of patients with clinical pregnancy indicators. Results: We found there was no significant difference in the results of general conditions in the two groups of patients, such as infertility age and duration, body mass index (BMI), basal follicle stimulating hormone (FSH), basal luteinizing hormone (LH), basal estrogen (E2) levels, the endometrial thickness, the number of transplanted high-quality embryos on the day of transplantation and so on (P > 0.05). We found that the implantation rate (32.55%), biochemical pregnancy rate (53.57%), and clinical pregnancy rate (51.78%) in group B were significantly higher than those in group A (25.26%, 35.11%, and 34.66%, respectively) (P < 0.05). We also found there is no significant difference in spontaneous abortion rate (15.30% vs 15.87%) and multiple pregnancy rate (13.61% vs 14.28%) between patients in group A and group B (P > 0.05). Conclusion: We conclude that patients who are scheduled for frozen embryo transfer use progesterone vaginal sustained release capsules combined with luteal progesterone luteal support, have improved clinical pregnancy rates.