BackgroundDespite advances in radiation therapy, chemotherapy, and newly developed molecular targeting therapies, long-term survival after resection for patients with NSCLC remains less than 50%. We investigated factors predicting postoperative locoregional recurrences and distant metastases in patients with clinical stage I non-small-cell lung cancer (NSCLC) after surgical resection.MethodsAll patients with clinical stage I NSCLC, who underwent surgical resection between January 2002 and June 2006, were reviewed retrospectively. Multiple logistic regression analyses were used to identify independent risk factors for patients with locoregional recurrences and distant metastases.ResultsA total of 261 patients were eligible. Overall survival was significant related to locoregional recurrences (P?=?0.03) and distant metastases (P 3.5 ng/mL) is the predictor of distant metastasis.ConclusionsTumor differentiation and serum CEA were predictors of postoperative relapse for clinical stage I NSCLC after surgical resection. Risk factors of postoperative recurrence in patients with clinical stage I NSCLC may enable us to optimize the patient selection for postoperative adjuvant therapies or neoadjuvant treatment before surgery.
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机译:背景技术尽管放疗,化学疗法和新开发的分子靶向疗法取得了进步,但NSCLC患者切除后的长期生存率仍不到50%。我们调查了手术切除后临床I期非小细胞肺癌(NSCLC)患者术后局部复发和远处转移的预测因素。回顾性审查。采用多因素logistic回归分析确定局部复发和远处转移的独立危险因素。结果共有261例患者入选。总生存率与局部复发显着相关(P≤0.03),远处转移(P 3.5 ng / mL)是远处转移的预测指标。结论肿瘤分化和血清CEA是手术切除后I期NSCLC临床复发的预测指标。 。临床I期NSCLC患者术后复发的危险因素可能使我们能够优化手术前辅助治疗或新辅助治疗的患者选择。
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