Metabolik Sendromda Peroksizom Proliferator-Aktive Edici Gamma (PPARg) Pro12Ala Genotipinin Sendrom Bile?enlerine Etkisi ve Diyet ile Etkile?imi - Original Makale

摘要

?zet Ama?: Metabolik sendrom abdominal obezite, insülin direnci, dislipidemi ve hipertansiyon ile karakterize olan kompleks bir hastal?kt?r. Sendromun, genetik ?zellikler ile diyet ba?ta olmak üzere ?e?itli ?evresel etmenlerin etkile?imi sonucu olu?tu?u bilinmektedir. Genetik bir farkl?l?k olu?turan peroksizom proliferator-aktive edici gamma (PPARg) genindeki Pro12Ala polimorfizminin metabolik sendrom patogenezinde rol oynayabilece?i ileri sürülmü?tür. Bu ?al??man?n amac?, metabolik sendromlu bireylerde PPARg Pro12Ala genotipine g?re sendrom bile?enlerinin da??l?m? ve bu da??l?m?n diyet ile ili?kini incelemektir. Gere? ve Y?ntemler: ?al??maya Uluslaras? Diyabet Federasyonu (UDF) kriterlerine g?re metabolik sendromlu olarak tan?mlanan 18-65 ya? aras?nda, 150 birey kat?lm??t?r. Hacettepe üniversitesi T?p Fakültesi Endokrinoloji ve Metabolizma ünitesi ve Sa?l?k Bilimleri Fakültesi Beslenme ve Diyetetik B?lümlerinde, kat?l?mc?lar?n fizik muayeneleri yap?lm??, antropometrik ?l?ümleri al?nm??, beslenme durumlar? de?erlendirilmi?, biyokimyasal ve genetik analizleri yap?lm??t?r. Bulgular: Polimorfizmin ?rneklemde g?rülme s?kl??? %14 (%1,3 AlaAla homozigot and %12,7 AlaPro heterozigot) olarak saptanm??t?r. UDF? in metabolik sendrom bile?eni olarak kabul etti?i abdominal obezite, bozulmu? glukoz tolerans?, plazma yüksek trigliserid düzeyi, plazma dü?ük HDL kolesterol düzeyi ve yüksek kan bas?nc?n?n g?rülme s?kl?klar?n?n PPARg genotipine g?re da??l?mlar? incelendi?inde, bu bile?enlerin da??l?mlar?n?n PPARg genotipine g?re farkl?l?k g?stermedi?i saptanm??t?r. Ayr?ca PPARg genotipinin diyet enerji ve makro besin ??elerine kar?? olu?turulan cevab? etkilemedi?i g?sterilmi?tir. Sonu?: Bu ?al??mada elde edilen sonu?lar PPARg Pro12Ala polimorfizmi ile metabolik sendromun ili?ki oldu?unu ve polimorfizmin diyete kar?? olu?turulan cevab? etkiledi?ini ileri süren hipotezleri desteklememektedir. Türk Jem 2010; 14: 54-9 Anahtar kelimeler: Metabolik sendrom, PPARg Pro12Ala polimorfizmi, diyet Abstract Objective: Metabolic syndrome is a highly prevalent complex disorder characterized by abdominal obesity, insulin resistance, dyslipidemia and hypertension. It occurs as a result of the interaction between genetic susceptibility and environmental factors, in particular, diet. The pro12Ala polymorphism of peroxisome proliferator-activated receptor gamma (PPARg), which generates a genetic diversity has been proposed to act in the pathogenesis of metabolic syndrome. The objectives of this study were to verify whether PPARg Pro12Ala polymorphism modulates the prevalence of the components of metabolic syndrome and whether dietary intake interacts with the polymorphism to modulate the features of syndrome. Materials and Methods: A total of 150 subjects (aged 18-65) diagnosed as having metabolic syndrome according to the International Diabetes Federation (IDF) criteria participated in the study. All subjects underwent a clinical, anthropometrical, biochemical and nutritional assessment and analysis of Pro12Ala polymorphism of PPARg at the Department of Nutrition and Dietetics and Department of Endocrinology - Metabolism, Hacettepe University. Results: The polymorphism was detected in 14% of the study population (1.3% - AlaAla homozygote and 12.7% - AlaPro heterozygote). The prevalence of any of the syndrome components defined by IDF did not differ significantly with PPARg genotype. In addition, no association was found between dietary intake and prevalence of metabolic syndrome components modified by PPARg Pro12Ala genotype. Conclusion: Our results suggest that PPARg Pro12Ala polymorphism is not associated with the metabolic syndrome components and cannot modulate the association between dietary intake and components of the metabolic syndrome. Turk Jem 2010; 14: 54-9