Electro-oxidation of some non-steroidal anti-inflammatory drugs on an alumina nanoparticle-modified glassy carbon electrode

摘要

The electro-oxidation of mefenamic acid, diclofenac, andindomethacin on glassy carbon and alumina nanoparticle-modified glassycarbon electrodes in a phosphate buffer solution at physiological pHwas studied. The techniques of cyclic voltammetry, chronoamperometry,impedance spectroscopy, and steady state polarization measurementswere applied. The drugs were irreversibly oxidized on bath electrodesvia an anodic peak and the process was controlled by diffusion in thebulk of solution. Alumina nanoparticles increased the oxidationcurrent, and lowered the peak and onset potentials. As such, aluminananoparticles had an electrocatalytic effect, both kinetically andthermodynamically. The kinetic parameters of heterogeneous electrontransfer and diffusion coefficients of the drugs are reported.