Silica nanoparticles as a high efficient catalyst for the one-pot synthesis of 3-oxo-3-phenylpropanamid derivatives from isocyanides, phenylacetaldehyde and secondary amines

摘要

Reaction of an isocyanide with an iminium ion intermediate,formed by reaction between 2-oxo-2-phenylacetaldehyde and a secondaryamine in the presence of silica nanoparticles, proceeds smoothly atroom temperature to afford ketoamide derivatives in high yields.