Targeting BRAFV600E with PLX4720 Displays Potent Antimigratory and Anti-invasive Activity in Preclinical Models of Human Thyroid Cancer

Andrew H. Fischer; Carmelo Nucera; Gideon E. Bollag; Jack Lawler; Matthew A. Nehs; Michal Mekel; Paul S. Lin; Peter M. Sadow; Richard A. Hodin; Sareh Parangi; Sushruta S. Nagarkatti

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Targeting BRAFV600E with PLX4720 Displays Potent Antimigratory and Anti-invasive Activity in Preclinical Models of Human Thyroid Cancer

机译：用PLX4720靶向BRAFV600E在人类甲状腺癌的临床前模型中显示有效的抗迁移和抗侵袭活性

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>Purpose. B-RafV600E may play a role in the progression from papillary thyroid cancer to anaplastic thyroid cancer (ATC). We tested the effects of a highly selective B-RafV600E inhibitor, PLX4720, on proliferation, migration, and invasion both in human thyroid cancer cell lines (8505cB-RafV600E and TPC-1RET/PTC-1 and wild-type B-Raf) and in primary human normal thyroid (NT) follicular cells engineered with or without B-RafV600E.

机译：>目的。B-Raf V600E 可能在甲状腺乳头状癌向间变性甲状腺癌（ATC）的发展中发挥作用。我们测试了高度选择性的B-Raf V600E 抑制剂PLX4720对人甲状腺癌细胞系（8505c B-RafV600E 和TPC-1 RET / PTC-1和野生型B-Raf ）以及经过或不经过B-Raf V600E 改造的原代人正常甲状腺（NT）滤泡细胞。

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《The oncologist》 |2011年第3期|共页
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Andrew H. Fischer; Carmelo Nucera; Gideon E. Bollag; Jack Lawler; Matthew A. Nehs; Michal Mekel; Paul S. Lin; Peter M. Sadow; Richard A. Hodin; Sareh Parangi; Sushruta S. Nagarkatti;
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1. Targeting BRAFV600E with PLX4720 displays potent antimigratory and anti-invasive activity in preclinical models of human thyroid cancer. [J] . Nucera C, Nehs MA, Nagarkatti SS, The oncologist . 2011,第3期

机译：用PLX4720靶向BRAFV600E在人类甲状腺癌的临床前模型中显示出强大的抗迁移和抗侵袭活性。
2. RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models. [J] . Yang H, Higgins B, Kolinsky K, Cancer research: The official organ of the American Association for Cancer Research, Inc . 2010,第13期

机译：选择性的BRAFV600E抑制剂RG7204（PLX4032）在临床前黑色素瘤模型中显示出强大的抗肿瘤活性。
3. SOMCL-085, a novel multi-targeted FGFR inhibitor,displays potent anticancer activity in FGFR-addicted human cancer models [J] . Xi-fei JIANG, Ying-hong SHI, Jing AI, 中国药理学报：英文版 . 2018,第002期

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4. Design, Synthesis, Biophysical and Structure-Activity Properties of a Novel Dual MDM2 and MDMX Targeting Stapled α-Helical Peptide: ATSP-7041 Exhibits Potent In Vitro and In Vivo Efficacy in Xenograft Models of Human Cancer [C] . V. Guerlavais, K. Darlak, B. Graves American Peptide Symposium . 2013

机译：新型双MDM2和MDMX靶向吻合α-螺旋肽的设计，合成，生物物理和结构 - 活性特性：ATSP-7041在体外表现出效率和体内人类癌症的模型
5. Briciclib (on 013105), an elF4E inhibitor, exhibits potent anti-cancer activity in various preclinical cancer models. [D] . Desai, Bina. 2015

机译：elF4E抑制剂Briciclib（在013105上）在各种临床前癌症模型中均显示出强大的抗癌活性。
6. Targeting BRAFV600E with PLX4720 Displays Potent Antimigratory and Anti-invasive Activity in Preclinical Models of Human Thyroid Cancer [O] . Carmelo Nucera, Matthew A. Nehs, Sushruta S. Nagarkatti, 2011

机译：用PLX4720靶向BRAFV600E在人类甲状腺癌的临床前模型中显示有效的抗迁移和抗侵袭活性
7. Targeting BRAFV600E with PLX4720 Displays Potent Antimigratory and Anti-invasive Activity in Preclinical Models of Human Thyroid Cancer [O] . Nucera, Carmelo, Nehs, Matthew A., Nagarkatti, Sushruta S., 2011

机译：用PLX4720靶向BRAFV600E在人类甲状腺癌的临床前模型中显示有效的抗迁移和抗侵袭活性

Targeting BRAFV600E with PLX4720 Displays Potent Antimigratory and Anti-invasive Activity in Preclinical Models of Human Thyroid Cancer

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