Facile and rapid synthesis of some novel polysubstituted imidazoles by employing magnetic Fe_3O_4 nanoparticles as a high efficient catalyst

摘要

Multicomponent, one-pot, highly efficient, andenvironmentally adapted synthesis of some novel polysubstitutedimidazoles by the use of various aldehydes, benzil, aliphatic, andaromatic primary amines and ammonium acetate in the presence ofFe_3O_4 nanoparticles as catalyst under solvent-free condition isexplained. A highly efficient role of Fe_3O_4 nanoparticles ascatalyst in this synthesis was shown. By this advantage, severalpolysubstituted imidazoles as pharmaceutical important molecules canbe prepared in high yield and high purity. This method is very easyand rapid for the synthesis of imidazole derivatives. All productswere deduced from their IR and NMR spectroscopic data. The Fe_3O_4nanoparticles were characterized by powdered X-ray diffraction (XRD),transmission electron microscopy (TEM), and FT-IR spectroscopy.