Anti-Hyperlipidemic Effect of Flavone-Rich Belamcanda chinensis (L.) DC. (Iridaceae) Leaf Extract in ICR Mice Fed High-Fat Diet

摘要

Purpose: To assess the anti-hyperlidemic effect of flavone-rich B. chinensis leaf extract (HTP) in ICR mice fed a high-fat diet. Methods: HTP (100, 200 and 400 mg/kg) were orally administered to ICR mice fed high-fat diet for 7 weeks. Blood glucose, as well as serum and hepatic levels of lipids were determined at the end of the experiment. Phosphorylation of adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) and protein level of peroxisome proliferator-activated receptor α (PPARα) were analyzed by Western blot and enzyme-linked immunosorbent assay (ELISA) kit, respectively. Results: Treatment with HTP significantly decreased peri-epididymal fat weight (p Conclusion: HTP can alleviate hyperlipidemia, at least in part, by up-regulation of AMPK and PPARα.