Anti-Hyperprolactinemic Effect of Formula Malt Decoction, a Chinese Herbal Cocktail

摘要

Purpose: To investigate the anti-hyperprolactinemic activity of Formula Malt Decoction (FMD), a Chinese herbal mixture. Methods: The effect of FMD on serum prolactin (PRL), estradiol (E2), progesterone (PGN), follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels were investigated in hyperprolactinemic (hyperPRL) rats. The effect of FMD on PRL secretion, dopamine D2 receptor and dopamine transporters (DAT) were studied in MMQ cells derived from rat pituitary adenoma cells, GH3 cells derived from rat pituitary lactotropic tumoral cells and PC12 cells from rat pheochromocytoma, respectively. Results: Compared with the model group, a high dose of FMD (11.6 g/kg body weight) and medium dose of FMD (5.8 g/kg body weight) reduced PRL level of hyperPRL rats effectively. In MMQ cells, treatment with 5 mg/ml FMD (p Conclusion: FMD shows anti-hyperprolactinemia activity via dopamine D2 receptor.