Secretory Leukocyte Protease Inhibitor and Helicobacter pylori in the Gastrointestinal Tract of HIV-infected Persons: A Review

摘要

Prevalence/incidence of Helicobater pylori (Hp) is reduced in HIV/AIDS. HIV-infection may alter the prevalence/incidence or pathology of Helicobacter pylori (Hp) infection. Secretory leukocyte protease inhibitor (SLPI) is an important broad spectrum innate immunity component that has anti-bacterial and HIV-1 inhibitory activity in different mucosal secretions and possibly in the local mucosal tissue milieu. Several human mucosal fluids contain SLPI which is an anti-microbial bio-molecule with anti-inflammatory and wound healing properties. SLPI plays an important role in gastric diseases. The underlying mechanisms should be clearly examined and elucidated. Reduced SLPI levels in the event of local infections are consistent with an increased risk of HIV infection. SLPI is produced in the gastrointestinal tract and may play an important role in Hp infection. We review the literature associated with SLPI and Hp to generate hypotheses and provide possible explanation for addressing the Hp prevalence/incidence issue in HIV/AIDS.