Mechanism analysis of Traditional Chinese Medicine in treatment of Diabetic Nephropathy based on network pharmacology and Traditional Chinese Medicine inheritance support system

摘要

Diabetic nephropathy is one of the most serious complications of diabetes mellitus. In the early stage, edema and proteinuria are the main clinical manifestations. In the later stage, glomerulosclerosis and interstitial fibrosis will occur. And the prognosis is poor. Nowadays, traditional Chinese medicine has a remarkable curative effect in the treatment of diabetic nephropathy. There are more and more studies on the treatment of diabetic nephropathy with traditional Chinese medicine, but most of them focus on the syndromes of diabetic nephropathy, which are short of in-depth research and summary on the mechanism of Chinese herbal prescriptions. In this paper, the traditional Chinese medicine inheritance support system and network pharmacology BATMAN-TCM software were used to collect and analyze the relevant literature. It was found that the core compatibility of Shanzhuyu, Fuling and Shuyu in the treatment of diabetic nephropathy is closely related to the signal transduction pathway and target of diabetic nephropathy, and has a positive effect on the improvement of clinical symptoms such as proteinuria, glycometabolism disorder, edema, etc. This paper explores the core compatibility of Shanzhuyu, Fuling and Shuyu on diabetic nephropathy, in order to provide reference for clinical treatment. HighlightsDiabetic nephropathy is one of the most serious complications of diabetes mellitus, which seriously affects the quality of life of patients for the poor prognosis. Nowadays, Traditional Chinese Medicine has a remarkable curative effect in the treatment of diabetic nephropathy, which has brought some enlightenment to our research ideas. Traditional Chinese Medicine Inheritance Assistant Platform System (TCM Inheritance Assistant Platform) is an organic combination of computer science and TCM. By intellectualized processing of disease prescription, the data of disease information, syndrome information and compatibility of TCM can be more intuitive, which make Chinese herbal medicine and drug pairs for treating diseases more specialized and precise. Network pharmacology is based on system biology to analyze multi-target networks of drugs, and can combine Drug targets with diseases, which make the treatment of diseases more targeted. This paper collects and summarizes the prescriptions of traditional Chinese medicine for diabetic nephropathy in the past 10 years from China Knowledge Net, and uses the system of traditional Chinese Medicine Inheritance assistant platform and BATMAN-TCM database of network pharmacology to analyze the medication rules and action signal pathways. We concluded that Shanzhuyu（Cornus officinalis Sieb. et Zucc）, Fuling (Poria cocos (Schw.) Wolf) and Shuyu (Dioscorea opposite) have certain positive effects on the compatibility in the prevention and treatment of diabetic nephropathy and hope to provide new ideas for the research and clinical treatment of diabetic nephropathy with TCM.